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KMID : 0904020080240010006
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Journal of Korean Society for Vascular Surgery
2008 Volume.24 No. 1 p.6 ~ p.10
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The Relationship between Brachial Ankle Pulse Wave Velocity and Atherosclerotic Risk Factors
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Kim Sung-Woo
Kim Kyu-Hong
Hwang Seong-Youn
Choi Seung-Ho
Lee Sun-Jung
Choi Young-Cheol
Jun Si-Youl
Park Jong-Kwon
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Abstract
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Purpose: Aging and atherosclerotic changes enhance the stiffness of the arterial wall, and the pulse wave travels faster in stiffer vessel. Measurement of the brachial ankle pulse wave velocity (baPWV) is a non-invasive method for evaluating the stiffness of the vessel wall. We investigated the relation between the baPWV and risk factors for atherosclerosis.
Method: We studied 180 subjects (38 male and 142 female; mean age 46 years, range 24 to 76 years). The instrument used for evaluating the baPWV was a Vasoguard (VIASYS Healthcare, Dublin, Ohio, USA), and measurements were performed in the right arm and in both ankles. Data were analyzed using Pearson correlation, t-test, and multiple regression analysis. Multiple regression analysis was performed for age, sex, smoking, hypertension, height, weight, body mass index (BMI), total cholesterol, LDL, HDL, TG, and HbA1c.
Result: Right and left baPWVs were significantly increased (P＜0.05) in subjects with the following risks: older age, high body weight, high BMI, high total cholesterol, high LDL, high TG, high HbA1c, and low HDL. Right and left baPWVs were also significantly increased (P＜0.05) in male subjects with a history of smoking and hypertension. Multiple regression analysis showed that age, sex, and LDL were independent determinants of the right and left baPWVs.
Conclusion: This study provides evidence that increased age, male gender, and high serum LDL levels are risk factors that contribute to arterial stiffness. Measurement of the baPWV may be a useful method for evaluating vascular status.
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KEYWORD
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Pulse, Wave, Velocity, Atherosclerotic risk factor
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